Extraction of bioactive compounds from Curcuma longa L. using deep eutectic solvents: In vitro and in vivo biological activities

In this work, deep eutectic solvents (DES-based menthol and cholinium chloride) the ethanol, temperature, times were selected to extract bioactive compounds from rhizome, leaves, flowers Curcuma longa L., using ultrasound-assisted extraction. Analyzes antioxidant, flavonoids, antimicrobial, chelation Fe2+, inhibition of cholinesterase's enzymes, cytotoxicity, genotoxicity in Allium cepa cells performed. The extracts showed results iron antibacterial. leaves' inhibited food spoilage bacteria with values above 45%, substantial iron-chelating activity 50%. Extracts obtained by DES based on lactic acid exhibited a high percentage acetyl butyryl cholinesterase. contrast, flower acetic low cholinesterase enzyme activity. No cytotoxicity genotoxicity. Biological activities potential for application these pharmaceutical industries.